Obesity in psoriasis: leptin and resistin as mediators of cutaneous inflammation

Obesity in psoriasis: leptin and resistin as mediators of cutaneous inflammation.

BACKGROUND Obesity is a significant risk factor for psoriasis and body mass index (BMI) correlates with disease severity. Objectives To investigate the relationship between obesity and psoriasis, focusing on the role of adipokines such as leptin and resistin. PATIENTS/METHODS Patients with psoriasis (n = 30) were recruited and their BMI, waist circumference and disease severity [Psoriasis Are...

Resistin, adiponectin, ghrelin, leptin, and proinflammatory cytokines: relationships in obesity.

OBJECTIVE To evaluate interactions among leptin, adiponectin, resistin, ghrelin, and proinflammatory cytokines [tumor necrosis factor receptors (TNFRs), interleukin-6 (IL-6)] in nonmorbid and morbid obesity. RESEARCH METHODS AND PROCEDURES We measured these hormones by immunoenzyme or radiometric assays in 117 nonmorbid and 57 morbidly obese patients, and in a subgroup of 34 morbidly obese pa...

Mediators of Inflammation in Obesity and Its Comorbidities

In the last decades we have seen a rapid expansion of the proportion of obese individuals worldwide. Actually obesity has gradually but also rather considerably revealed as a whole medical problem with menacing implications for the health of our society. Indeed, obesity is already of epidemic proportions in the U.S. and in many other parts of the world and it is a worrying problem also in devel...

Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several risk factors promote AF, among which diabetes mellitus has emerged as one of the most important. The growing recognition that obesity, diabetes and AF are closely intertwined disorders has spurred major interest in uncovering their mechanistic links. In this article we provide an update on the growing ev...

obesity, leptin and leptin receptors